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They are both free and I find PCB123 the easiest to work with. You can use Eagle to generate gerber files etc. so you can send the data for making custom PCB's from just about anywhere. In PCB123 you can do something similar but you can only send it to the PCB123 company for fabrication. They both have Schematic/PCB drawing editors and the free version of Eagle limits the board size, where PCB123 is full function. PCB123 has quite a good support/help base as well.