I do it (well not every day) all the time. I only built the programmer half of the Junebug, so all I have is the 10 pin connector going off board. I have built several of Nigel's boards, adding an ICSP socket to them. 16F648A, 16F877A, 18F1320, 18F4450, etc. Program or Debug. (Well not the 648A).