Hi, Mr Deb, the PICKIT2 users guide says you are only supposed to connect the VSS(GND), VDD, TX and RX pins with the PICKIT2( PG#69). Also, the power pins are necessary. If you are going to use the PICKIT2 UART Tool for debugging only, than why use the UART tool, why not the debugging tool itself? Also just looked at the schematic, in order to use the PICKIT2s UART tool, the PICKIT2 pins are to be connected to the TX, RX pins of the target chip in addition to the power pins. So according to your schematic you are not making connections for the UART Tool.