It really depends what you're trying to do?, their output isn't 100W anyway, it's only 60/70W RMS at a fairly high distortion of 0.5%. However, by bridging two of them, thus using four, you could get 120/140W in to 8 ohms - bridging doesn't increase power, it allows the same power to a different impedance (each chip is providing 60/70W to 4 ohms). However, bridging increases distortion even more, and probably isn't a good idea. You would also need a different supply, as 8 ohm is +/-35V maximum, and 4 ohm is +/-27V maximum, and required for bridging to an 8 ohm load.
For home audio use a single TDA7294 per channel and 60/70W is plenty more power than you're going to need anyway, and as they shouldn't be running hard anyway, distortion will be considerably lower than when hitting the absolute maximum power.
Bear in mind volume is logarithmic, so 100W is only twice as loud as 10W - unless you live in a vast mansion, and have highly inefficient speakers, two single ended TDA7294's should be plenty.
I've seen various guitar amps using these chips, they seem to work pretty well, and are quite reliable - and they don't tend to use expensive huge heatsinks, despite their much higher power levels and considerable abuse.