How big of a change, how fast of a change, which direction is the change, do you need to know the direction of change ....
A window comparator will set a low and high level for the voltage and if it moves outside that range, will trip the comparator. But if you want the thing to stay "tripped" and not reset back to normal on a quick transition, you'll have to follow up the comparator with another circuit (e.g., an RS flip flop) that will retain the trip.
Dean