Normally you enable high at the start of the program... Any high priority interrupt you have selected will now be operational.
If you have to do a "time critical task" ie writing to internal eeprom.. Then disable high is used before the write and enable high after... If you are using low priority interrupts there is enable / disable low as well..
I'm combining two programs together, which need to be together to work. There are only ENABLE HIGH in both programs, and as it is 'time critical' I will assume that I don't need ENABLE LOW.