PIC and VB connection

Hello! I definitely does not have any idea on how PIC and VB will be able to communicate with each other. Can somebody help me with the codes?

While having VB communicate with a PIC and vice versa is possible through a serial port (for example); if you post what you have done so far, or have a specific question about a certain part of your application to help solve an issue you have been having, we may be able to help.