I actually work for Voodoo Lab (formerly Digital Music Corporation) as their tech support. We make the Ground Control Pro MIDI foot controller along with the GCX Guitar Audio Switcher. Both devices use an 8031/8032 as the brain.
The Marshall JMP-1 MIDI preamp also used an 8031 as the brain.
Guitar devices (unless you're using a guitar synth) use only a small spectrum of MIDI...Program Change, Control Change, and Bank Select. We use it mainly for switching multiple devices in/out of the signal path, patch/scene memory recall, as well as controlling a parameter setting in real time via an expression pedal, CC On/Off messages and controlling banks on processors that have more than 128 "patches" as those are done in multiple banks of 100 or so.
I don't plan to build any sort of MIDI devices that involve any sort of Velocity or Note On/Off like synthesizers do. I'm only using it as a control protocol. But since every other manufacturer of MIDI guitar gear uses the 8051 family of uC's the higher end PIC line would be an option to explore as it would make my devices different from everyone elses.