Again... Controllerless or controller???
If you plan to use a controllerless system you need to manage the screen... You'll need a BIG micro... A good deal of ARM chips provide an LCD interface... Microchip's pic32 can do controllerless but takes up timers and other resources..
If you buy a screen with a "Built in" controller... SSD1963 or other.. You just tell the controller what to do..
Some have onboard memory and SD interface which makes it far easier for you!! Way back during the PC revolution, the displays had a special card (still do ) which will do all the mundane stuff...
MikroC provides low level access to controllers.... But there are MANY examples on the net... I have mono graphical libraries that I use with MikroC... for several different controllers..