hi alex,
What are the dimensions of the pcb area that will require a four layer pcb layout.?
You could consider the main pcb as being double layer and a small 4 layer 'piggy back' pcb for the USB2 module.
Leave sufficient area clear on the main pcb for the 4 layer pcb.
The 4 layer pcb would be mounted on pickup pins on the main pcb.
I have used a similar method for mounting smaller pcbs to a main pcb.
If this explaination is not clear enough, please ask.