The very best I have found to be commonsense.exe which when coupled with other software works quite well. Seriously, my opinion is the software that works best for the end user and their Internet Surfing Habits as well as their Email Volume and how they treat that volume. Personally I use the MS Security Suite at home on all my systems as well as my wife's system. This works well for us and our situation. When I was more active with this sort of stuff and reading up more on it every month every AV software review listed something else over the month before. It just got old after awhile and for the most part was BS.
Just My Take
Ron

